2,970 hectares; Landscape representation - Eastern Shore Quartzite Plain; Eastern Shore Drumlins

Located along the eastern shore of the Liscomb River in western Guysborough County, Liscomb River Wilderness Area is characterized by a mosaic of low, broad deciduous hills and ridges, coniferous flats, bedrock ridges, and hummocky terrain. There are also scattered deciduous drumlins, bedrock ridge barrens, and variously sized wetlands.
Big Stillwater, a lake near the southern boundary of the area, is recognized as an area of exceptional habitat diversity with outstanding wildlife value, which is of provincial significance. Forming much of the western boundary of the wilderness area, the Liscomb River and its associated waterbodies support healthy Atlantic Salmon and native trout populations. In addition the Liscomb River provides habitats for fur-bearing mammals such as beaver, muskrat, otters, weasels, and mink, as well as providing nesting sites for osprey. The provincially rare wood turtle is also associated with the river.
The river is also well known as a high-water canoeing destination, while adjacent logging roads and cart-tracks provide access for a variety of overnight wilderness trips. Also, the southern boundary of the Liscomb River Wilderness Area is located approximately 2 km from Liscombe Lodge, a well known tourist resort. Liscomb Lodge is involved in a variety of wilderness-oriented activities which include kayaking challenging sections of white-water, hiking, interpretation, and scenic appreciation.